Team II Genome Assembly Group

Introduction

Background

Antibiotic resistance has been called one of the world’s most pressing public health problems. Antibiotic resistance is the ability of bacteria to resist the effects of an antibiotic. It occurs when bacteria change in a way that reduces the effectiveness of drugs, chemicals, or other agents designed to cure or prevent infections. The bacteria survive and continue to multiply, causing more harm (Figure 1.a.). Antibiotic resistance can cause illnesses that were once easily treatable with antibiotics to become dangerous infections, prolonging suffering for children and adults. Antibiotic-resistant bacteria can spread to family members, schoolmates, and co-workers, and may threaten your community (Figure 1.b). Antibiotic-resistant bacteria are often more difficult to kill and more expensive to treat and in some cases, can lead to serious disability or even death [1].

Figure 1: a. How antibiotic resistance happens, b. How antibiotic resistance spreads

Data

Emory Antibiotic Resistance Center (ARC) in Emory University, School of medicine tries to better understand antibiotic resistance to combat this crisis and improve human health. Their goals include learning how antibiotic resistance develops, optimizing the way antibiotics are used to preserve their power, and discovering novel therapeutics and vaccines to directly combat antibiotic-resistant pathogens. Solving the crisis of antibiotic resistance requires a multi-faceted approach that crosses traditional boundaries. They Provided us with a sample of 262 pair-end raw reads of Klebsiella spp, from illumina ....

Objectives

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