Team II Gene Prediction Group

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Introduction

Gene Prediction

Data

Approaches

1. Ab-initio

2. Comparative


Ab-initio Approaches

Comparative Approaches

Comparative, similarity based or Homology based gene prediction uses previously sequenced genes and their protein products as a template for recognition of unknown genes in a newly sequenced DNA fragments. So, in short we cab say: It is using "Known Genes" to predict "New Genes".

Figure 2: Given a known gene and an unannotated genome sequence, find a set of substrings in the genomic sequence whose concatenation best matches the known gene

Recently, the number of sequenced genomes has increased drastically and 99% of genes have homologous partner, 80% have orthologous partner and 85 % identity (protein coding DNA) versus 69 % identity (intronic DNA). All these can be considered as the motivation of using this method of gene prediction.